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In lab experiments, mice taking drugs ran faster and longer than normal mice on treadmill tests. The animals that received AICAR, the other drugs, was 44 percent longer than untreated animals. The second compound, GW1516 had more dramatic effects on endurance, but only when it is combined with exercise.

Ronald M. Evans, Howard Hughes Medical Institute researcher, who led study, said drugs that mimic exercise could offer effective protection from obesity and metabolic disorders. They can also help to counter the devastating effects of wasting diseases like muscular dystrophy.

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